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Catalog_noBDAB0045
Product_nameRecombinant SARS-CoV-2 (2019-nCoV) NSP8 protein
Category冠状病毒产品
ApplicationsImmunogen
Size50ug/100ug/1mg
Price1800/2800/8800
SpecificitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
FormulationSupplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5
SourceE.coli
Storage_stabilityUse a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 2 to 8 °C for one week .Store at -20 to -80 °C for twelve months from the date of receipt.
othernameSARS-CoV 2 nsp8
BackgroundCleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. Nsp8 was shown to have RNA-dependent RNA polymerase (RdRp) activity that could be involved in producing primers utilized by nsp12 which is normally accepted to be the RdRp for SARS-CoV.
NotesNSP8
descriptionRecombinant SARS-CoV-2 NSP8 is produced by E.coli expression system and the target gene encoding Ala1-Gln198 is expressed with N-His Tag
TypeN-His
Purity>90% as determined by SDS-PAGE
Molecular Weight24.18kDa
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